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Senthilkumar, N.
- Synthesis And Biological Evaluation of New S-Mannich Bases of 3-Methyl-4-Phenyl-3,4,5,6,7,8, Hexahydroquinazoline-2(1h)-Thione
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1 Department of Pharmaceutical Chemistry, JKKMMRF College of Pharmacy, B. Komarapalayam, Namakkal, Tamil Nadu – 638 183, IN
1 Department of Pharmaceutical Chemistry, JKKMMRF College of Pharmacy, B. Komarapalayam, Namakkal, Tamil Nadu – 638 183, IN
Source
Asian Journal of Research in Chemistry, Vol 4, No 10 (2011), Pagination: 1573-1577Abstract
The chalcone was synthesized from cyclohexanone and an aromatic aldehyde by aldol condensation reaction, followed by cyclisation with thiourea results in hexahydro quinazoline. The third position is methylated by using methyl iodide, finally the mannich reaction was carried out with five different amines at second position of the hexahydro quinazoline to get five different S-Mannich bases. All the 5 synthesized new compounds were studied for their physiochemical characters. And their structures were confirmed by spectral studies (IR, NMR). These new derivatives were evaluated for analgesic and anti-inflammatory activity.
Keywords
S-Mannich Bases, Quinazoline, Chalcone.- Simultaneous Estimation of Telmisartan and Pioglitazone in Pharmaceutical Dosage Form by RP-HPLC Method
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1 J.K.K. Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam-638183, Namakkal Dt, Tamilnadu, IN
1 J.K.K. Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam-638183, Namakkal Dt, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 364-366Abstract
A simple, precise, accurate, rapid and reproducible RP-HPLC procedure was developed for simultaneous estimation of Telmisartan and Pioglitazone in pharmaceutical dosage form at a single wavelength. The mobile phase used was a combination of acetonitrile:0.5% triethylamine (pH 4.5 with orthophosphoric acid) (65:35). The detection of the combined dosage form was carried out at 210 nm and flow rate set 1.3 ml/mins. Linearity obtained in the concentration range of 10 to 50 μg/ml for Telmisartan and 7.5 to 37.5 μg/ml for Pioglitazone with correlation coefficient of 0.9997 and 0.9995 respectively. The result of analysis were validated statistically recovery studies confirmed by the accuracy of the proposed method.Keywords
Simultaneous Estimation by RP-HPLC, Telmisartan, Pioglitazone.- Simultaneous RP-HPLC Method Development and Validation of Cefixime and Ofloxacin in Tablet Dosage Form
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1 J.K.K. Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam-638183, Namakkal Dt, Tamilnadu, IN
1 J.K.K. Munirajah Medical Research Foundation, College of Pharmacy, Komarapalayam-638183, Namakkal Dt, Tamilnadu, IN
Source
Asian Journal of Research in Chemistry, Vol 3, No 2 (2010), Pagination: 367-369Abstract
A simple, precise, accurate, rapid and reproducible RP-HPLC procedure was developed for simultaneous determination of Cefixime and Ofloxacin in tablet dosage form at a single wavelength. The determination was carried out by using Phenomenox, Gemini C18, Column (50×4.6 mm) with mobile phase used as a combination of acetonitrile:0.05 M Tetra butyl ammonium Hydrogen Sulphate (pH 6.0 with orthophosphoric acid) (35:65). The detection of the combined dosage form was carried out at 290 nm and flow rate set 2.0 ml/min. Linearity obtained in the concentration range of 160 and 240 Cefixime and Ofloxacin with correlation coefficient of 0.9999 and 0.9999 respectively. The result of the analysis were validated statistically and recovery studies confirmed by the accuracy of the proposed method.Keywords
Cefixime, Ofloxacin and RP-HPLC.- Bioanalytical Method Development and Validation of Esomepraole in Human Plasma by LCMS/Ms
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Authors
Affiliations
1 Department of Pharmaceutical Analysis, J.K.K.Munirajah Medical Research Foundation College of Pharmacy, The Dr. M.G.R. Medical University, Komarapalayam-638183, Namakkal Dt, Tamilnadu, IN
1 Department of Pharmaceutical Analysis, J.K.K.Munirajah Medical Research Foundation College of Pharmacy, The Dr. M.G.R. Medical University, Komarapalayam-638183, Namakkal Dt, Tamilnadu, IN